Oct.24 in the Journal of Clinical Investigation.
Over time, the static, obese state of the mice reset the “normal,” body weight set point to become permanently elevated, despite dieting that initially worked to shed pounds, authors say.
“Our model demonstrates that obesity is in part a self-perpetuating disorder and the results further emphasize the importance of early intervention in childhood to try to prevent the condition whose effects can last a lifetime,” says senior author Malcolm J. Low, M.D., Ph.D., professor of molecular and integrative physiology and internal medicine (see also University of Michigan Health System).

NOTES FROM SYD:
1. This shouldn’t be an excuse for you to throw up your hands and say “oh well, I guess it’s too late”. It should motivate you to get up and do something if you’ve been procrastinating.
2. For those of you who’ve spent some time carrying around extra weight, hope is at hand! The same principle can work in reverse. Just like holding the weight on can establish a new “set weight” so can holding the weight off! Clinically I’ve seen plenty of people lose LOTS of weight and keep it off long enough (years) to create a new LOWER set weight. Yes, it takes a bit of work at first and can be tough to maintain until it gets “locked” in, but it IS doable. :)We can help you.

Come on in. Let’s get you taken care of. ~ Bliss